目前改造的受体包括蛋白激酶、各种代谢酶和G蛋白偶联受体（GPCRs）等。2007年诞生的由设计药物专一激活设计受体（Designer receptors exclusively activated by designer drugs,DREADDs）技术是指只由叠氮平-N-氧化物（Clozapine-N-oxide，CNO）激活的受体，这些受体会选择性地作用于不同的GPCR级联反应来调节细胞信号转导，包括Gq、Gi、GsD、Golf和β-arrestin，其中应用最广泛的是Gq-DREADD和Gi-DREADD。
图1.化学遗传学里经改造的受体
表1 化学遗传病毒产品现货列表
| 名称 | 功能描述 | 产品编号 | 产品名称 | 启动子 | Cre/Flp依赖 | 标签 |
| hM3D(Gq) | 化学遗传激活 | PT-0525 | rAAV-CaMKIIa-hM3D(Gq)-EGFP-WPRE-hGH polyA | CaMKIIα | EGFP | |
| PT-0049 | rAAV-CaMKIIa-hM3D(Gq)-mCherry-WPREs | CaMKIIα | mCherry | |||
| PT-0138 | rAAV-TRE3g-hM3D(Gq)-mCherry-WPRE-hGH polyA | TRE3g | mCherry | |||
| PT-0152 | rAAV-hSyn-hM3D(Gq)-EGFP-WPRE-hGH polyA | hSyn | EGFP | |||
| PT-1580 | rAAV-CaMKIIa-DIO-hM3D(Gq)-EGFP-WPREs | CaMKIIα | Cre依赖 | EGFP | ||
| PT-1144 | rAAV-CaMKIIa -DIO-hM3D(Gq)-mCherry-WPRE-pA | CaMKIIα | Cre依赖 | mCherry | ||
| PT-0891 | rAAV-hSyn-DIO-hM3D(Gq)-EGFP-WPREs | hSyn | Cre依赖 | EGFP | ||
| PT-0019 | rAAV-hSyn-DIO-hM3D(Gq)-mCherry-WPRE-hGH polyA | hSyn | Cre依赖 | mCherry | ||
| PT-0816 | rAAV-EF1α-DIO-hM3D(Gq)-EYFP-WPRE-hGH polyA | EF1α | Cre依赖 | EYFP | ||
| PT-0042 | rAAV-EF1α-DIO-hM3D(Gq)-mCherry-WPREs | EF1α | Cre依赖 | mCherry | ||
| PT-0855 | PFD-rAAV-CAG-DIO-hM3D(Gq)-mCherry-WPRE-hGH polyA | CAG | Cre依赖 | mCherry | ||
| PT-0294 | PFD-rAAV-CMV-DIO-hM3D(Gq)-mCherry-WPRE-hGH polyA | CMV | Cre依赖 | mCherry | ||
| hM4D(Gi) | 化学遗传抑制 | PT-0017 | rAAV-CaMKIIa-hM4D(Gi)-mCherry-WPRE-hGH polyA | CaMKIIα | mCherry | |
| PT-0020 | rAAV-hSyn-DIO-hM4D(Gi)-mCherry-WPRE-hGH polyA | hSyn | Cre依赖 | mCherry | ||
| PT-0043 | rAAV-EF1α-DIO-hM4D(Gi)-mCherry-WPREs | EF1α | Cre依赖 | mCherry | ||
| PT-0153 | rAAV-hSyn-hM4D(Gi)-EGFP-WPRE-hGH polyA | hSyn | EGFP | |||
| PT-0159 | rAAV-nEF1a-fDIO-hM4D(Gi)-EGFP-WPRE-hGH polyA | nEF1α | Flp依赖 | EGFP | ||
| PT-0170 | rAAV-hSyn-fDIO-hM4D(Gi)-mCherry-WPRE-hGH polyA | hSyn | Flp依赖 | mCherry | ||
| PT-0344 | rAAV-hSyn-DIO-hM4D(Gi)-EYFP-WPRE-hGH polyA | hSyn | Cre依赖 | EYFP | ||
| PT-0524 | rAAV-CaMKIIa-hM4D(Gi)-EGFP-WPRE-hGH polyA | CaMKIIα | EGFP | |||
| PT-0815 | rAAV-EF1α-DIO-hM4D(Gi)-EYFP-WPREs | EF1α | Cre依赖 | EYFP | ||
| PT-0856 | rAAV-CAG-DIO-hM4D(Gi)-mCherry-WPRE-hGH polyA | CAG | Cre依赖 | mCherry | ||
| PT-1080 | rAAV-CMV-DIO-hM4D(Gi)-P2A-mCherry-hGH polyA | CMV | Cre依赖 | mCherry | ||
| PT-1143 | rAAV-CaMKIIa-DIO-hM4D(Gi)-mCherry-WPRE-hGH polyA | CaMKIIα | Cre依赖 | mCherry | ||
| PT-1505 | PFD-rAAV-CaMKIIa-DO-hM4D(Gi)-mCherry-WPRE-hGH polyA | CaMKIIα | Creoff | mCherry | ||
| PT-1572 | rAAV-hSyn-Con Fon-hM4D(Gi)-EGFP-WPRE-hGH polyA | hSyn | Creon/Flpon | EGFP | ||
| KORD | 化学遗传抑制 | PT-0123 | rAAV-CaMKIIa-HA-KORD-IRES-mCitrine-WPRE-hGH polyA | CaMKIIα | mCitrine | |
| PT-0122 | rAAV-hSyn-DIO-HA-KORD-IRES-mCitrine-WPRE-hGH polyA | hSyn | mCitrine |
更多产品欢迎电话咨询！
信息订阅
我们将及时向您推送最新产品资讯
市场：027-65023363 行政/人事：027-62439686 邮箱：marketing@brainvta.com
销售总监：张经理 18995532642 华东区：陈经理 18013970337 华南区：王经理 13100653525 华中/西区：杨经理 18186518905 华北区：张经理 18893721749
地址：中国武汉东湖高新区光谷七路128号中科开物产业园1号楼
Copyright © 武汉枢密脑科学技术有限公司. All RIGHTS RESERVED.
鄂ICP备2021009124号 DIGITAL BY VTHINK
