产品名称
UN45A Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/55898
Human Swissprot No.
Q9H3U1
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9H3U1/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/101869
Mouse Swissprot No.
Q99KD5
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q99KD5
Rat Gene Link
https://www.uniprot.org/uniprot/308759
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q32PZ3
免疫原
Synthesized peptide derived from human UN45A AA range: 259-309
特异性
This antibody detects endogenous levels of UN45A at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
UNC45A plays a role in cell proliferation and myoblast fusion, binds progesterone receptor (PGR; MIM 607311) and HSP90 (HSPCA; MIM 140571), and acts as a regulator of the progesterone receptor chaperoning pathway (Price et al., 2002 [PubMed 12356907]; Chadli et al., 2006 [PubMed 16478993]).[supplied by OMIM, Mar 2008],
组织表达
Detected in peripheral blood leukocytes, bone marrow, adrenal gland, trachea, spinal cord, thyroid, lymph node and stomach.
细胞定位
Cytoplasm . Cytoplasm, perinuclear region . Nucleus . Predominant in the perinuclear region. Little protein in the nucleus.
功能
function:Acts as co-chaperone for HSP90. Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive factor in promoting PGR function in the cell. May be necessary for proper folding of myosin (Potential). Necessary for normal cell proliferation. Necessary for normal myotube formation and myosin accumulation during muscle cell development. May play a role in erythropoiesis in stroma cells in the spleen.,similarity:Contains 3 TPR repeats.,subcellular location:Predominant in the perinuclear region. Little protein in the nucleus.,subunit:Interacts with PGR isoforms A and B as well as with NR3C1 in the absence of ligand, and with HSP90AB1. Binding to HSP90AB1 involves 2 UNC45A monomers per HSP90AB1 dimer.,tissue specificity:Detected in peripheral blood leukocytes, bone marrow, adrenal gland, trachea, spinal cord, thyroid, lymph node and stomach.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
