产品名称
GPT Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/1798
Human Swissprot No.
Q9H3H5
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9H3H5/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/13478
Mouse Swissprot No.
P42867
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P42867
免疫原
Synthesized peptide derived from human GPT AA range: 209-259
特异性
This antibody detects endogenous levels of GPT at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is an enzyme that catalyzes the first step in the dolichol-linked oligosaccharide pathway for glycoprotein biosynthesis. This enzyme belongs to the glycosyltransferase family 4. This protein is an integral membrane protein of the endoplasmic reticulum. The congenital disorder of glycosylation type Ij is caused by mutation in the gene encoding this enzyme. [provided by RefSeq, Jul 2008],
细胞定位
Endoplasmic reticulum membrane; Multi-pass membrane protein .
功能
catalytic activity:UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UMP + N-acetyl-D-glucosaminyl-diphosphodolichol.,disease:Defects in DPAGT1 are the cause of congenital disorder of glycosylation type 1J (CDG1J) [MIM:608093]. CDGs are a family of severe inherited diseases caused by a defect in protein N-glycosylation. They are characterized by under-glycosylated serum proteins. These multisystem disorders present with a wide variety of clinical features, such as disorders of the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions.,function:Catalyzes the initial step in the synthesis of dolichol-P-P-oligosaccharides.,online information:GlycoGene database,online information:UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase,pathway:Protein modification; protein glycosylation.,similarity:Belongs to the glycosyltransferase 4 family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
