产品名称
ATS3 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/9508
Human Swissprot No.
O15072
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O15072/entry
免疫原
Synthesized peptide derived from human ATS3 AA range: 600-650
特异性
This antibody detects endogenous levels of ATS3 at Human
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease, a member of the procollagen aminopropeptidase subfamily of proteins, may play a role in the processing of type II fibrillar collagen in articular cartilage. [provided by RefSeq, Feb 2016],
组织表达
Found in cartilage and skin.
细胞定位
Secreted . Secreted, extracellular space, extracellular matrix .
功能
caution:Has sometimes been referred to as ADAMTS4.,cofactor:Binds 1 zinc ion per subunit.,domain:The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.,function:Cleaves the propeptides of type II collagen prior to fibril assembly. Does not act on types I and III collagens.,PTM:The precursor is cleaved by a furin endopeptidase.,similarity:Contains 1 disintegrin domain.,similarity:Contains 1 peptidase M12B domain.,similarity:Contains 1 PLAC domain.,similarity:Contains 4 TSP type-1 domains.,tissue specificity:Found in cartilage and skin.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
