产品名称
CLC4E Rabbit Polyclonal Antibody
基因名称
CLEC4E CLECSF9 MINCLE UNQ218/PRO244
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/26253
Human Swissprot No.
Q9ULY5
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9ULY5/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/56619
Mouse Swissprot No.
Q9R0Q8
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9R0Q8
Rat Gene Link
https://www.uniprot.org/uniprot/450223
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q67EQ1
免疫原
Synthesized peptide derived from human CLC4E AA range: 46-96
特异性
This antibody detects endogenous levels of CLC4E at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein is a downstream target of CCAAT/enhancer binding protein (C/EBP), beta (CEBPB) and may play a role in inflammation. Alternative splice variants have been described but their full-length sequence has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008],
组织表达
Expressed in monocytes and macrophages.
细胞定位
Cell membrane ; Single-pass type II membrane protein . Cell projection, phagocytic cup .
功能
function:May play a role in the response to inflammatory stimuli in peritoneal macrophages. May be involved in immune surveillance processes under transcriptional control of CEBPB.,online information:Mincle,similarity:Contains 1 C-type lectin domain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
