产品名称
KIF1B Rabbit Polyclonal Antibody
基因名称
KIF1B KIAA0591 KIAA1448
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/23095
Human Swissprot No.
O60333
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O60333/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/16561
Mouse Swissprot No.
Q60575
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q60575
Rat Gene Link
https://www.uniprot.org/uniprot/117548
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/O88658
免疫原
Synthesized peptide derived from human KIF1B AA range: 1331-1381
特异性
This antibody detects endogenous levels of KIF1B at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a motor protein that transports mitochondria and synaptic vesicle precursors. Mutations in this gene cause Charcot-Marie-Tooth disease, type 2A1. [provided by RefSeq, Jul 2008],
组织表达
Isoform 3 is abundant in the skeletal muscle. It is also expressed in fetal brain, lung and kidney, and adult heart, placenta, testis, ovary and small intestine. Isoform 2 is abundant in the brain and also expressed in fetal heart, lung, liver and kidney, and adult skeletal muscle, placenta, liver, kidney, heart, spleen, thymus, prostate, testis, ovary, small intestine, colon and pancreas.
细胞定位
Cytoplasm, cytoskeleton. Mitochondrion . Cell projection, axon .; [Isoform 1]: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle .
功能
disease:Defects in KIF1B are the cause of Charcot-Marie-Tooth disease type 2A1 (CMT2A1) [MIM:118210]. CMT2A1 is a form of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathy or CMT1, and primary peripheral axonal neuropathy or CMT2. Neuropathies of the CMT2 group are characterized by signs of axonal regeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy.,function:Motor for anterograde transport of mitochondria. Has a microtubule plus end-directed motility.,similarity:Belongs to the kinesin-like protein family.,similarity:Belongs to the kinesin-like protein family. Unc-104 subfamily.,similarity:Contains 1 FHA domain.,similarity:Contains 1 kinesin-motor domain.,similarity:Contains 1 PH domain.,subunit:Interacts with KBP.,tissue specificity:Isoform 3 is abundant in the skeletal muscle. It is also expressed in fetal brain, lung and kidney, and adult heart, placenta, testis, ovary and small intestine. Isoform 2 is abundant in the brain and also expressed in fetal heart, lung, liver and kidney, and adult skeletal muscle, placenta, liver, kidney, heart, spleen, thymus, prostate, testis, ovary, small intestine, colon and pancreas.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
