产品名称
SO4C1 Rabbit Polyclonal Antibody
基因名称
SLCO4C1 OATP4C1 OATPX SLC21A20
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/353189
Human Swissprot No.
Q6ZQN7
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q6ZQN7/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/227394
Mouse Swissprot No.
Q8BGD4
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8BGD4
Rat Gene Link
https://www.uniprot.org/uniprot/432363
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q71MB6
免疫原
Synthesized peptide derived from human SO4C1 AA range: 77-127
特异性
This antibody detects endogenous levels of SO4C1 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
SLCO4C1 belongs to the organic anion transporter (OATP) family. OATPs are involved in the membrane transport of bile acids, conjugated steroids, thyroid hormone, eicosanoids, peptides, and numerous drugs in many tissues (Mikkaichi et al., 2004 [PubMed 14993604]).[supplied by OMIM, Mar 2008],
组织表达
Predominantly expressed in kidney but also weakly expressed in both fetal liver and kidney.
细胞定位
Basolateral cell membrane ; Multi-pass membrane protein . Detected at the basolateral membrane of the proximal tubule cell in the kidney. .
功能
function:Organic anion transporter, capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate and cAMP. May participate in the regulation of membrane transport of ouabain. Involved in the uptake of the dipeptidyl peptidase-4 inhibitor sitagliptin and hence may play a role in its transport into and out of renal proximal tubule cells. May be involved in the first step of the transport pathway of digoxin and various compounds into the urine in the kidney. May be involved in sperm maturation by enabling directed movement of organic anions and compounds within or between cells. This ion-transporting process is important to maintain the strict epididymal homeostasis necessary for sperm maturation. May have a role in secretory functions since seminal vesicle epithelial cells are assumed to secrete proteins involved in decapacitation by modifying surface proteins to facilitate the acquisition of the ability to fertilize the egg.,miscellaneous:SLCO4C1-mediated digoxin uptake is inhibited by digoxin itself and related compounds such as ouabain, digitoxin and digoxigenin.,similarity:Belongs to the organo anion transporter (TC 2.A.60) family.,subcellular location:Detected at the basolateral membrane of the proximal tubule cell in the kidney.,tissue specificity:Predominantly expressed in kidney but also weakly expressed in both fetal liver and kidney.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
