产品名称
EI2BE Rabbit Polyclonal Antibody
蛋白名称
Translation initiation factor eIF-2B subunit epsilon (eIF-2B GDP-GTP exchange factor subunit epsilon)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q13144
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q13144/entry
Mouse Swissprot No.
Q8CHW4
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8CHW4
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q64350
免疫原
Synthesized peptide derived from human protein . at AA range: 480-560
特异性
EI2BE Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter. [provided by RefSeq, Nov 2009],
组织表达
Brain,Epithelium,Hepatocyte,Lung,Platelet,
细胞定位
nucleus,cytoplasm,cytosol,eukaryotic translation initiation factor 2B complex,
功能
disease:Defects in EIF2B5 are a cause of leukodystrophy with vanishing white matter (VWM) [MIM:603896]. VWM is a leukodystrophy that occurs mainly in children. Neurological signs include progressive cerebellar ataxia, spasticity, inconstant optic atrophy and relatively preserved mental abilities. The disease is chronic-progressive with, in most individuals, additional episodes of rapid deterioration following febrile infections or minor head trauma. While childhood onset is the most common form of the disorder, some severe forms are apparent at birth. A severe, early-onset form seen among the Cree and Chippewayan populations of Quebec and Manitoba is called Cree leukoencephalopathy. Milder forms may not become evident until adolescence or adulthood. Some females with milder forms of the disease who survive to adolescence exhibit ovarian dysfunction. This variant of the disorder is called ovarioleukodystrophy.,function:Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.,similarity:Belongs to the EIF-2B gamma/epsilon subunits family.,similarity:Contains 1 W2 domain.,subunit:Complex of five different subunits; alpha, beta, gamma, delta and epsilon.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
