BD-PN0011

PASK Rabbit Polyclonal Antibody

常规抗体

PASK KIAA0135

PAS domain-containing serine/threonine-protein kinase (PAS-kinase) (PASKIN) (hPASK) (EC 2.7.11.1)

WB

Human,Mouse

1 mg/ml

Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.

23178

Q96RG2

https://www.uniprot.org/uniprotkb/Q96RG2/entry

Q8CEE6

http://www.uniprot.org/uniprot/Q8CEE6

Synthesized peptide derived from human protein . at AA range: 1100-1180

PASK Polyclonal Antibody detects endogenous levels of protein.

WB 1:500-2000 ELISA 1:5000-20000

145kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene encodes a member of the serine/threonine kinase family that contains two PAS domains. Expression of this gene is regulated by glucose, and the encoded protein plays a role in the regulation of insulin gene expression. Downregulation of this gene may play a role in type 2 diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011],

Ubiquitously expressed, with slightly higher expression in brain, prostate and testis. Reduced expression was found in placenta. Present in germ cells of testis and in the midpiece of sperm tails (at protein level).

Cytoplasm . Nucleus . Localizes in the nucleus of testis germ cells and in the midpiece of sperm tails.

catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Activated by autophosphorylation on Thr-1161 and Thr-1165 and inhibited by the first PAS domain.,PTM:Autophosphorylated on Thr-1161 and Thr-1165.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 PAS (PER-ARNT-SIM) domains.,tissue specificity:Ubiquitously expressed, with slightly higher expression in brain, prostate and testis. Reduced expression was found in placenta.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.