产品名称
DCMC Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/23417
Human Swissprot No.
O95822
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O95822/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/56690
Mouse Swissprot No.
Q99J39
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q99J39
Rat Gene Link
https://www.uniprot.org/uniprot/85239
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q920F5
免疫原
Synthesized peptide derived from human DCMC AA range: 243-293
特异性
This antibody detects endogenous levels of DCMC at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
The product of this gene catalyzes the breakdown of malonyl-CoA to acetyl-CoA and carbon dioxide. Malonyl-CoA is an intermediate in fatty acid biosynthesis, and also inhibits the transport of fatty acyl CoAs into mitochondria. Consequently, the encoded protein acts to increase the rate of fatty acid oxidation. It is found in mitochondria, peroxisomes, and the cytoplasm. Mutations in this gene result in malonyl-CoA decarboyxlase deficiency. [provided by RefSeq, Jul 2008],
组织表达
Expressed in fibroblasts and hepatoblastoma cells (at protein level). Expressed strongly in heart, liver, skeletal muscle, kidney and pancreas. Expressed in myotubes. Expressed weakly in brain, placenta, spleen, thymus, testis, ovary and small intestine.
细胞定位
Cytoplasm . Mitochondrion matrix . Peroxisome . Peroxisome matrix . Enzymatically active in all three subcellular compartments. .
功能
catalytic activity:Malonyl-CoA = acetyl-CoA + CO(2).,disease:Defects in MLYCD are the cause of malonyl-CoA decarboxylase deficiency (MLYCD deficiency) [MIM:248360]. MLYCD deficiency is an autosomal recessive disease characterized by abdominal pain, chronic constipation, episodic vomiting, metabolic acidosis and malonic aciduria.,function:Catalyzes the conversion of malonyl-CoA to acetyl-CoA. In the fatty acid biosynthesis MCD selectively removes malonyl-CoA and thus assures that methyl-malonyl-CoA is the only chain elongating substrate for fatty acid synthase and that fatty acids with multiple methyl side chains are produced. In peroxisomes it may be involved in degrading intraperoxisomal malonyl-CoA, which is generated by the peroxisomal beta-oxidation of odd chain-length dicarboxylic fatty acids.,pathway:Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from malonyl-CoA: step 1/1.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
