产品名称
FBXL4 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/26235
Human Swissprot No.
Q9UKA2
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9UKA2/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/269514
Mouse Swissprot No.
Q8BH70
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8BH70
免疫原
Synthesized peptide derived from human FBXL4 AA range: 396-446
特异性
This antibody detects endogenous levels of FBXL4 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the F-box protein family, which are characterized by an approximately 40 amino acid motif, the F-box. F-box proteins constitute one subunit of modular E3 ubiquitin ligase complexes, called SCF complexes, which function in phosphorylation-dependent ubiquitination. The F-box domain mediates protein-protein interactions and binds directly to S-phase kinase-associated protein 1. In addition to an F-box domain, the encoded protein contains at least 9 tandem leucine-rich repeats. The ubiquitin ligase complex containing the encoded protein may function in cell-cycle control by regulating levels of lysine-specific demethylase 4A. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],
组织表达
Expressed in heart, kidney, liver, lung, pancreas, and placenta, but not in skeletal muscle.
细胞定位
Cytoplasm. Nucleus. Mitochondrion.
功能
similarity:Contains 1 F-box domain.,similarity:Contains 8 LRR (leucine-rich) repeats.,subunit:Part of a SCF (SKP1-cullin-F-box) protein ligase complex.,tissue specificity:Expressed in heart, kidney, liver, lung, pancreas, and placenta, but not in skeletal muscle.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
