产品名称
HIPK1 Rabbit Polyclonal Antibody
基因名称
HIPK1 KIAA0630 MYAK NBAK2
蛋白名称
Homeodomain-interacting protein kinase 1 (EC 2.7.11.1) (Nuclear body-associated kinase 2)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q86Z02
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q86Z02/entry
Mouse Swissprot No.
O88904
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O88904
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941A4L9P5
免疫原
Synthesized peptide derived from human protein . at AA range: 290-370
特异性
HIPK1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
homeodomain interacting protein kinase 1(HIPK1) Homo sapiens The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms. [provided by RefSeq, Jul 2008],
组织表达
Ubiquitously expressed with highest levels in skeletal muscle and heart. Overexpressed in breast cancer cell lines. Isoform 2 is highly expressed in testis. Expressed in both androgen-dependent and androgen-independent prostate cancer cells (PubMed:28289210).
细胞定位
Nucleus . Cytoplasm . Nucleus speckle . Predominantly nuclear. Translocates from nucleus to cytoplasm in response to stress stimuli via SENP1-mediated desumoylation. .
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:May play a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. May be involved in malignant squamous cell tumor formation.,PTM:Autophosphorylated. Phosphorylated and activated by JNK1.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily.,similarity:Contains 1 protein kinase domain.,subcellular location:Predominantly nuclear.,subunit:Interacts with Nkx1-2 and Nkx2-5 (By similarity). Interacts with DAXX and TP53.,tissue specificity:Ubiquitously expressed with highest levels in skeletal muscle and heart. Overexpressed in breast cancer cell lines.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
