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MTMR5 Rabbit Polyclonal Antibody

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产品基本信息

产品货号
BD-PN4111
产品名称
MTMR5 Rabbit Polyclonal Antibody
类别
常规抗体
基因名称
SBF1 MTMR5
蛋白名称
MTMR5
推荐应用
WB
反应种属
Human,Mouse
浓度
1 mg/ml
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene ID
6305
Human Gene Link
https://www.uniprot.org/uniprot/6305
Human Swissprot No.
O95248
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O95248/entry
Mouse Gene ID
77980
Mouse Gene Link
https://www.uniprot.org/uniprot/77980
Mouse Swissprot No.
Q6ZPE2
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q6ZPE2
免疫原
Synthesized peptide derived from human MTMR5 AA range: 320-370
特异性
This antibody detects endogenous levels of MTMR5 at Human/Mouse
稀释度
WB 1:500-2000
参考分子量
205kD
运输及保存条件
-20°C/1 year
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the protein-tyrosine phosphatase family. However, the encoded protein does not appear to be a catalytically active phosphatase because it lacks several amino acids in the catalytic pocket. This protein contains a Guanine nucleotide exchange factor (GEF) domain which is necessary for its role in growth and differentiation. Mutations in this gene have been associated with Charcot-Marie-Tooth disease 4B3. Pseudogenes of this gene have been defined on chromosomes 1 and 8. [provided by RefSeq, Dec 2014],
细胞定位
Cytoplasm . Cytoplasm, perinuclear region .
功能
function:Probable pseudophosphatase. Lacks several amino acids in the catalytic pocket which renders it catalytically inactive as a phosphatase. The pocket is however sufficiently preserved to bind phosphorylated substrates, and maybe protect them from phosphatases. Inhibits myoblast differentiation in vitro and induces oncogenic transformation in fibroblasts.,similarity:Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.,similarity:Contains 1 dDENN domain.,similarity:Contains 1 DENN domain.,similarity:Contains 1 GRAM domain.,similarity:Contains 1 myotubularin phosphatase domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 uDENN domain.,subunit:Interacts with the SET domain of MLL/HRX. Interacts with SUV39H1.,
期货
现货
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

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