BD-PN0021

ACINU Rabbit Polyclonal Antibody

常规抗体

ACIN1 ACINUS KIAA0670

Apoptotic chromatin condensation inducer in the nucleus (Acinus)

WB

Human,Mouse

1 mg/ml

Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.

22985

Q9UKV3

https://www.uniprot.org/uniprotkb/Q9UKV3/entry

Q9JIX8

http://www.uniprot.org/uniprot/Q9JIX8

Synthesized peptide derived from human protein . at AA range: 1120-1200

ACINU Polyclonal Antibody detects endogenous levels of protein.

WB 1:500-2000

147kD

-20°C/1 year

Polyclonal, Rabbit,IgG

Apoptosis is defined by several morphologic nuclear changes, including chromatin condensation and nuclear fragmentation. This gene encodes a nuclear protein that induces apoptotic chromatin condensation after activation by caspase-3, without inducing DNA fragmentation. This protein has also been shown to be a component of a splicing-dependent multiprotein exon junction complex (EJC) that is deposited at splice junctions on mRNAs, as a consequence of pre-mRNA splicing. It may thus be involved in mRNA metabolism associated with splicing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011],

Ubiquitous. The Ser-1180 phosphorylated form (by SRPK2) is highly expressed and phosphorylated in patients with myeloid hematologic malignancies.

Nucleus. Nucleus speckle. Nucleus, nucleoplasm. Phosphorylation on Ser-1180 by SRPK2 redistributes it from the nuclear speckles to the nucleoplasm.

Spliceosome;

function:Induces apoptotic chromatin condensation after activation by CASP3.,PTM:Undergoes proteolytic cleavage; the processed form is active, contrary to the uncleaved form.,similarity:Contains 1 SAP domain.,subunit:Interacts with API5.,tissue specificity:Ubiquitous.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.