产品名称
S22AC Rabbit Polyclonal Antibody
基因名称
SLC22A12 OATL4 URAT1 UNQ6453/PRO34004
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/116085
Human Swissprot No.
Q96S37
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q96S37/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/20521
Mouse Swissprot No.
Q8CFZ5
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8CFZ5
Rat Gene Link
https://www.uniprot.org/uniprot/365398
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q3ZAV1
免疫原
Synthesized peptide derived from human S22AC AA range: 18-68
特异性
This antibody detects endogenous levels of S22AC at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of the organic anion transporter (OAT) family, and it acts as a urate transporter to regulate urate levels in blood. This protein is an integral membrane protein primarily found in epithelial cells of the proximal tubule of the kidney. An elevated level of serum urate, hyperuricemia, is associated with increased incidences of gout, and mutations in this gene cause renal hypouricemia type 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013],
组织表达
Detected in kidney (at protein level). Detected in fetal and adult kidney. Detected in epithelial cells of proximal tubules in renal cortex.
细胞定位
Cell membrane ; Multi-pass membrane protein . Apical cell membrane ; Multi-pass membrane protein .
功能
disease:Defects in SLC22A12 are a cause of renal hypouricemia (RH) [MIM:220150]. Patients have low serum urate levels, due to defects in renal urate re-absorption and high urinary urate excretion. Patients often appear asymptomatic, but may be subject to exercise-induced acute renal failure (ARF), chronic renal dysfunction and uric acid urolithiasis.,function:Required for efficient urate re-absorption in the kidney. Regulates blood urate levels. Mediates saturable urate uptake by facilitating the exchange of urate against organic anions.,similarity:Belongs to the major facilitator superfamily. Organic cation transporter family.,subcellular location:Detected in the luminal membrane of the epithelium of renal proximal tubules.,subunit:Interacts with PDZK1.,tissue specificity:Detected in kidney (at protein level). Detected in fetal and adult kidney. Detected in epithelial cells of proximal tubules in renal cortex.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
