产品名称
BTBD1 Rabbit Polyclonal Antibody
基因名称
BTBD1 C15orf1 NS5ATP8
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/53339
Human Swissprot No.
Q9H0C5
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9H0C5/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/83962
Mouse Swissprot No.
P58544
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P58544
免疫原
Synthesized peptide derived from human BTBD1 AA range: 115-165
特异性
This antibody detects endogenous levels of BTBD1 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
The C-terminus of the protein encoded by this gene binds topoisomerase I. The N-terminus contains a proline-rich region and a BTB/POZ domain (broad-complex, Tramtrack and bric a brac/Pox virus and Zinc finger), both of which are typically involved in protein-protein interactions. Subcellularly, the protein localizes to cytoplasmic bodies. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],
组织表达
Ubiquitous; highest levels in testes, heart and skeletal muscle.
细胞定位
Cytoplasm . Localizes to punctate or elongated cytoplasmic bodies. .
功能
caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,function:Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 BTB (POZ) domain.,subcellular location:Cytoplasmic bodies.,subunit:Interacts with topoisomerase 1 and with TRIM5 isoform Delta. Interacts with CUL3.,tissue specificity:Ubiquitous; higher levels in heart and skeletal muscle.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
