产品名称
TRPC6 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/7225
Human Swissprot No.
Q9Y210
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9Y210/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/22068
Mouse Swissprot No.
Q61143
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q61143
免疫原
Synthesized peptide derived from human TRPC6 AA range: 412-462
特异性
This antibody detects endogenous levels of TRPC6 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2). [provided by RefSeq, Mar 2009],
组织表达
Expressed primarily in placenta, lung, spleen, ovary and small intestine. Expressed in podocytes and is a component of the glomerular slit diaphragm.
细胞定位
Cell membrane ; Multi-pass membrane protein .
功能
disease:Defects in TRPC6 are the cause of focal segmental glomerulosclerosis 2 (FSGS2) [MIM:603965]. FSGS2 is an autosomal dominant disease characterized by increased urinary protein excretion (proteinuria) and decreasing kidney function (nephrotic syndrome). Renal insufficiency often progresses to end-stage renal disease (ESRD) (also known as end-stage renal failure), a highly morbid state requiring either dialysis therapy or kidney transplantation.,function:Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion.,similarity:Belongs to the transient receptor family. STrpC subfamily.,similarity:Contains 4 ANK repeats.,subunit:Interacts with MX1 and RNF24.,tissue specificity:Expressed primarily in placenta, lung, spleen, ovary and small intestine. Expressed in podocytes and is a component of the glomerular slit diaphragm.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
