产品名称
GMCLL Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Swissprot No.
Q8NEA9
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8NEA9/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/100040533
Mouse Swissprot No.
Q99N64
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q99N64
免疫原
Synthesized peptide derived from human GMCLL AA range: 20-70
特异性
This antibody detects endogenous levels of GMCLL at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This locus shares a high degree of identity with the multi-exon germ cell-less gene on chromosome 2. Despite its single-exon nature, this chromosome 5 locus contains an open reading frame that could putatively encode a full-length germ cell-less related protein. [provided by RefSeq, Jul 2008],
组织表达
Expressed predominantly in testis.
功能
function:Possible function in spermatogenesis. Enhances the degradation of MDM2 and increases the amount of p53 probably by modulating the nucleocytoplasmic transport (By similarity). Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.,function:Possible function in spermatogenesis. Enhances the degradation of MDM2 and increases the amount of p53 probably by modulating the nucleocytoplasmic transport.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 BTB (POZ) domain.,subunit:Interacts with TMPO-beta, TSG101 and TFDP2 (By similarity). Interacts with EMD.,subunit:Interacts with TMPO-Beta, TSG101 and TFDP2. Interacts with EMD (By similarity). Interacts with CUL3.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
