产品名称
ADAM2 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/2515
Human Swissprot No.
Q99965
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q99965/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/11495
Mouse Swissprot No.
Q60718
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q60718
Rat Gene Link
https://www.uniprot.org/uniprot/56806
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q63202
免疫原
Synthesized peptide derived from human ADAM2 AA range: 109-159
特异性
This antibody detects endogenous levels of ADAM2 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded protein is a subunit of an integral sperm membrane glycoprotein called fertilin, which plays an important role in sperm-egg interactions. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013],
组织表达
Expressed specifically in spermatogenic cells in the seminiferous cells. Not detected in fetal tissues.
细胞定位
Membrane; Single-pass type I membrane protein.
功能
domain:A tripeptide motif (FEE) within disintegrin-like domain could be involved in the binding to egg integrin receptor and thus could mediate sperm/egg binding.,function:Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein.,miscellaneous:In mammals, exists as a heterodimer composed of an alpha and beta subunits. In human, fertilin subunit alpha is a pseudogene.,PTM:The prodomain and the metalloprotease domain are cleaved during the epididymal maturation of the spermatozoa.,similarity:Contains 1 disintegrin domain.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 peptidase M12B domain.,tissue specificity:Expressed specifically in spermatogenic cells in the seminiferous cells. Not detected in fetal tissues.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
