产品名称
ASCC1 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/51008
Human Swissprot No.
Q8N9N2
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8N9N2/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/69090
Mouse Swissprot No.
Q9D8Z1
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9D8Z1
免疫原
Synthesized peptide derived from human ASCC1 AA range: 289-339
特异性
This antibody detects endogenous levels of ASCC1 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a subunit of the activating signal cointegrator 1 (ASC-1) complex. The ASC-1 complex is a transcriptional coactivator that plays an important role in gene transactivation by multiple transcription factors including activating protein 1 (AP-1), nuclear factor kappa-B (NF-kB) and serum response factor (SRF). The encoded protein contains an N-terminal KH-type RNA-binding motif which is required for AP-1 transactivation by the ASC-1 complex. Mutations in this gene are associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011],
细胞定位
Nucleus . Nucleus speckle . Colocalizes with PRPF8 in nuclear speckles in the absence of DNA damage. .
功能
function:Enhances NF-kappa-B, SRF and AP1 transactivation.,similarity:Contains 1 KH domain.,subunit:Part of TRIP4 complex, that contains ASCC1, ASCC2 and ASCC3.,tissue specificity:Ubiquitous.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
