产品名称
Claudin-2 Mouse Monoclonal Antibody(8H11)
基因名称
CLDN2 PSEC0059 SP82 UNQ705/PRO1356
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Swissprot No.
P57739
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P57739/entry
免疫原
Synthesized peptide derived from human Claudin-2
特异性
This antibody detects endogenous levels of human Claudin-2
稀释度
WB 1:500-2000; IF ICC 1:100-500;IHC
背景介绍
This gene product belongs to the claudin protein family whose members have been identified as major integral membrane proteins localized exclusively at tight junctions. Claudins are expressed in an organ-specific manner and regulate tissue-specific physiologic properties of tight junctions. This protein is expressed in the intestine. Alternatively spliced transcript variants with different 5' untranslated region have been found for this gene.[provided by RefSeq, Jan 2010],
组织表达
Colon,Colon epithelium,Kidney,Skin,Teratocarcinoma,Thalamus,
细胞定位
Cell junction, tight junction . Cell membrane ; Multi-pass membrane protein .
功能
function:Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.,similarity:Belongs to the claudin family.,subunit:Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN3, but not CLDN1, homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.,
纯化
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
