产品名称
AIP Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/9049
Human Swissprot No.
O00170
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O00170/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/11632
Mouse Swissprot No.
O08915
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O08915
Rat Gene Link
https://www.uniprot.org/uniprot/282827
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5FWY5
免疫原
Synthesized peptide derived from human AIP AA range: 251-301
特异性
This antibody detects endogenous levels of AIP at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a receptor for aryl hydrocarbons and a ligand-activated transcription factor. The encoded protein is found in the cytoplasm as part of a multiprotein complex, but upon binding of ligand is transported to the nucleus. This protein can regulate the expression of many xenobiotic metabolizing enzymes. Also, the encoded protein can bind specifically to and inhibit the activity of hepatitis B virus. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014],
组织表达
Widely expressed. Higher levels seen in the heart, placenta and skeletal muscle. Not expressed in the liver.
功能
disease:Defects in AIP are a cause of ACTH-secreting pituitary adenoma [MIM:219090]; also known as pituitary Cushing disease. Cushing disease is a condition associated with increased blood cortisol resulting from adrenocorticotropic hormone (ACTH)-producing pituitary tumors that are resistant to glucocorticoid negative feedback.,disease:Defects in AIP are a cause of familial isolated pituitary adenoma (FIPA) [MIM:102200].,disease:Defects in AIP are a cause of growth hormone-secreting pituitary adenoma [MIM:102200]; also known as familial isolated somatotropinomas (FIS) or isolated familial somatotropinoma (IFS) or familial somatotrophinoma or acromegaly due to pituitary adenoma.,disease:Defects in AIP are a cause of pituitary adenoma predisposition (PAP) [MIM:102200].,function:Cellular negative regulator of the hepatitis B virus (HBV) X protein.,function:May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.,similarity:Contains 1 PPIase FKBP-type domain.,similarity:Contains 2 TPR repeats.,tissue specificity:Widely expressed. Higher levels seen in the heart, placenta and skeletal muscle. Not expressed in the liver.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
