产品名称
GTR10 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/81031
Human Swissprot No.
O95528
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O95528/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/170441
Mouse Swissprot No.
Q8VHD6
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8VHD6
免疫原
Synthesized peptide derived from human GTR10 AA range: 233-283
特异性
This antibody detects endogenous levels of GTR10 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the class III facilitative glucose transporter family. The encoded protein plays a role in regulation of glucose homeostasis. Mutations in this gene have been associated with arterial tortuosity syndrome.[provided by RefSeq, Dec 2009],
组织表达
Widely expressed; highest levels in liver and pancreas.
细胞定位
Endomembrane system ; Multi-pass membrane protein . Cytoplasm, perinuclear region .
功能
disease:Defects in SLC2A10 are the cause of arterial tortuosity syndrome (ATS) [MIM:208050]. ATS is an autosomal recessive disorder characterized by tortuosity and elongation of major arteries, often resulting in death at young age. Other typical features include aneurysms of large arteries and stenosis of the pulmonary artery, in association with facial features and several connective tissue manifestations such as soft skin and joint laxity. Histopathological findings include fragmentation of elastic fibers in the tunica media of large arteries.,function:Facilitative glucose transporter.,similarity:Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.,tissue specificity:Widely expressed; highest levels in liver and pancreas.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
