产品名称
CCDC6 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/8030
Human Swissprot No.
Q16204
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q16204/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/76551
Mouse Swissprot No.
D3YZP9
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/D3YZP9
免疫原
Synthesized peptide derived from human CCDC6 AA range: 104-154
特异性
This antibody detects endogenous levels of CCDC6 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a coiled-coil domain-containing protein. The encoded protein is ubiquitously expressed and may function as a tumor suppressor. A chromosomal rearrangement resulting in the expression of a fusion gene containing a portion of this gene and the intracellular kinase-encoding domain of the ret proto-oncogene is the cause of thyroid papillary carcinoma.[provided by RefSeq, Sep 2010],
组织表达
Ubiquitously expressed.
细胞定位
Cytoplasm. Cytoplasm, cytoskeleton . May be a cytoskeletal protein.
功能
disease:A chromosomal aberration involving CCDC6 is a cause of thyroid papillary carcinoma (PACT) [MIM:188550]. Inversion inv(10)(q11.2;q21) generates the RET/CCDC6 (PTC1) oncogene.,domain:The protein has mostly an alpha helical conformation similar to myosin heavy-chain tail that might adopt a coiled-coil conformation.,subcellular location:May be a cytoskeletal protein.,tissue specificity:Ubiquitously expressed.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
