产品名称
SETBP Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/26040
Human Swissprot No.
Q9Y6X0
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9Y6X0/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/240427
Mouse Swissprot No.
Q9Z180
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9Z180
免疫原
Synthesized peptide derived from human SETBP AA range: 990-1040
特异性
This antibody detects endogenous levels of SETBP at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein which contains a several motifs including a ski homology region and a SET-binding region in addition to three nuclear localization signals. The encoded protein has been shown to bind the SET nuclear oncogene which is involved in DNA replication. Mutations in this gene are associated with Schinzel-Giedion midface retraction syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011],
组织表达
Expressed in numerous tissues. Expressed at low levels in myeloid and monocytic cells as well as in CD34+ cells; expression levels are higher in myeloid malignancies.
功能
similarity:Contains 3 A.T hook DNA-binding domains.,subunit:Interacts with SET.,tissue specificity:Expressed in numerous tissues.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
