产品名称
EST5A Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/221223
Human Swissprot No.
Q6NT32
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q6NT32/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/67935
Mouse Swissprot No.
Q6AW46
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q6AW46
Rat Gene Link
https://www.uniprot.org/uniprot/307660
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5GRG2
免疫原
Synthesized peptide derived from human EST5A AA range: 278-328
特异性
This antibody detects endogenous levels of EST5A at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They also participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene, also called CES5, is predominantly expressed in peripheral tissues, including brain, kidney, lung and testis. It encodes a secreted enzyme. Because of high levels in the urine of male domestic cats, this enzyme is also called cauxin (carboxylesterase-like urinary excreted protein). The enzyme functions in regulating the production of a pheromone precursor and may contribute to lipid and cholesterol transfer processes within male reproductive fluids. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010],
功能
catalytic activity:A carboxylic ester + H(2)O = an alcohol + a carboxylate.,caution:Was named CES5 by Ref.1.,function:Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs.,PTM:N-glycosylated.,similarity:Belongs to the type-B carboxylesterase/lipase family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
