产品名称
SGPP1 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/81537
Human Swissprot No.
Q9BX95
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9BX95/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/81535
Mouse Swissprot No.
Q9JI99
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9JI99
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q99P55
免疫原
Synthesized peptide derived from human SGPP1 AA range: 47-97
特异性
This antibody detects endogenous levels of SGPP1 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite that regulates diverse biologic processes. SGPP1 catalyzes the degradation of S1P via salvage and recycling of sphingosine into long-chain ceramides (Mandala et al., 2000 [PubMed 10859351]; Le Stunff et al., 2007 [PubMed 17895250]).[supplied by OMIM, Jun 2009],
组织表达
Ubiquitous, with the strongest level in placenta and kidney.
细胞定位
Endoplasmic reticulum membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein .
功能
function:Has enzymatic activity against both sphingosine 1 phosphate (S1P) and dihydro-S1P. Regulates intracellular and extracellular S1P levels.,similarity:Belongs to the type 2 lipid phosphate phosphatase family.,tissue specificity:Ubiquitous, with the strongest level in placenta and kidney.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
