产品名称
EXOSX Rabbit Polyclonal Antibody
基因名称
EXOSC10 PMSCL PMSCL2 RRP6
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/5394
Human Swissprot No.
Q01780
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q01780/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/50912
Mouse Swissprot No.
P56960
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P56960
免疫原
Synthesized peptide derived from human EXOSX AA range: 391-441
特异性
This antibody detects endogenous levels of EXOSX at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
细胞定位
Cytoplasm. Nucleus, nucleolus. Nucleus. Strongly enriched in the nucleolus and a small amount has been found in cytoplasm supporting the existence of a nucleolar RNA exosome complex form.
功能
disease:Antibodies against PM/SCL are found in patients with polymyositis and/or scleroderma.,function:Part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Component of the exosome 3'->5' exoribonuclease complex, a complex that degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions. Required for the 3'processing of the 7S pre-RNA to the mature 5.8S rRNA. Could be an exonuclease (By similarity). Mediates the association of MTR4, C1D and MPP6 wth the exosome and this complex is required for the maturation of 5.8S rRNA. Required for nucleolar localization of C1D.,similarity:Contains 1 3'-5' exonuclease domain.,similarity:Contains 1 HRDC domain.,subunit:Component of the exosome multienzyme ribonuclease complex composed of at least 11 proteins: EXOSC1/CSL4, EXOSC2/RRP4, EXOSC3/RRP40, EXOSC4/RRP41, EXOSC5/RRP46, EXOSC6/MTR3, EXOSC7/RRP42, EXOSC8/RRP43, EXOSC9/Scl-75, DIS3/RRP44, and EXOSC10/Scl-100 (only in the nuclear complex). Found in a mRNA decay complex with RENT1, RENT2 and RENT3B. Also associated with the GTPase Ran (By similarity). Interacts with PTGES2. Interacts with C1D. Forms a heterotrimeric complex with C1D and MPP6 in vitro.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
