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IF4A3 Rabbit Polyclonal Antibody

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产品基本信息

产品货号
BD-PN3998
产品名称
IF4A3 Rabbit Polyclonal Antibody
类别
常规抗体
基因名称
EIF4A3 DDX48 KIAA0111
蛋白名称
IF4A3
推荐应用
WB
反应种属
Human,Mouse,Rat
浓度
1 mg/ml
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene ID
9775
Human Gene Link
https://www.uniprot.org/uniprot/9775
Human Swissprot No.
P38919
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P38919/entry
Mouse Gene ID
192170
Mouse Gene Link
https://www.uniprot.org/uniprot/192170
Mouse Swissprot No.
Q91VC3
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q91VC3
Rat Gene ID
688288
Rat Gene Link
https://www.uniprot.org/uniprot/688288
Rat Swissprot No.
Q3B8Q2
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q3B8Q2
免疫原
Synthesized peptide derived from human IF4A3 AA range: 218-268
特异性
This antibody detects endogenous levels of IF4A3 at Human/Mouse/Rat
稀释度
WB 1:500-2000
参考分子量
45kD
运输及保存条件
-20°C/1 year
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a nuclear matrix protein. Its amino acid sequence is highly similar to the amino acid sequences of the translation initiation factors eIF4AI and eIF4AII, two other members of the DEAD box protein family. [provided by RefSeq, Jul 2008],
组织表达
Ubiquitously expressed.
细胞定位
Nucleus . Nucleus speckle . Cytoplasm . Nucleocytoplasmic shuttling protein. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Detected in dendritic layer as well as the nuclear and cytoplasmic (somatic) compartments of neurons. Colocalizes with STAU1 and FMR1 in dendrites (By similarity). .
功能
function:Binds to spliced mRNAs and is involved in nonsense-mediated decay of mRNAs containing premature stop codons.,similarity:Belongs to the DEAD box helicase family. eIF4A subfamily.,similarity:Contains 1 helicase ATP-binding domain.,similarity:Contains 1 helicase C-terminal domain.,subunit:Identified in the spliceosome C complex, at least composed of AQR, ASCC3L1, C19orf29, CDC40, CDC5L, CRNKL1, DDX23, DDX41, DDX5, DGCR14, DHX35, DHX38, DHX8, EFTUD2, EIF4A3, FRG1, GPATC1, HNRPA1, HNRPA2B1, HNRPA3, HNRPC, HNRPF, HNRPH1, HNRPK, HNRPM, HNRPR, HNRPU, KIAA1160, KIAA1604, LSM2, LSM3, MAGOH, MORG1, PABPC1, PLRG1, PNN, PPIE, PPIL1, PPIL3, PPWD1, PRPF19, PRPF4B, PRPF6, PRPF8, RALY, RBM22, RBM8A, RBMX, SART1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B3, SFRS1, SKIV2L2, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNW1, SRRM1, SRRM2, SYF2, SYNCRIP, TFIP11, THOC4, U2AF1, WDR57, XAB2 and ZCCHC8. Part of the exon junction complex (EJC), a multisubunit complex which assembles near mRNA exon-exon junctions and which contains proteins involved in mRNA splicing, export, localization and nonsense-mediated decay. May interact with NOM1.,tissue specificity:Ubiquitously expressed.,
期货
现货
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

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