产品名称
UN93B Rabbit Polyclonal Antibody
基因名称
UNC93B1 UNC93 UNC93B
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/81622
Human Swissprot No.
Q9H1C4
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9H1C4/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/54445
Mouse Swissprot No.
Q8VCW4
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8VCW4
免疫原
Synthesized peptide derived from human UN93B AA range: 347-397
特异性
This antibody detects endogenous levels of UN93B at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein that is involved in innate and adaptive immune response by regulating toll-like receptor signaling. The encoded protein traffics nucleotide sensing toll-like receptors to the endolysosome from the endoplasmic reticulum. Deficiency of the encoded protein has been associated with herpes simplex encephalitis. [provided by RefSeq, Feb 2014],
组织表达
Expressed in plasmocytoid dendritic cells (at protein level). Highly expressed in antigen-presenting cells. Expressed in heart, and at lower level in kidney. Expressed at low level in other tissues.
细胞定位
Endoplasmic reticulum membrane ; Multi-pass membrane protein . Endosome . Lysosome . Cytoplasmic vesicle, phagosome . Relocalizes from endoplasmic reticulum to endosome and lysosome upon cell-stimulation with CpG dinucleotides (By similarity). Colocalizes with LAMP5 in large endosomal intracellular vesicles. .
功能
disease:Defects in UNC93B1 are associated with susceptibility to herpes simplex encephalitis (HSE) [MIM:610551]. HSE is a rare complication of human herpesvirus 1 (HHV-1) infection, occurring in only a small minority of HHV-1 infected individuals. HSE is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fever, headache, seizures, stupor, and often coma, frequently with a fatal outcome. UNC93B-deficient HSE does not compromise immunity to most pathogens, unlike most known primary immunodeficiencies.,online information:UNC93B1 mutation db,similarity:Belongs to the unc-93 family.,tissue specificity:Expressed in heart, heart, and at lower level in kidney. Expressed at low level in other tissues.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
