产品名称
TRPM4 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/54795
Human Swissprot No.
Q8TD43
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8TD43/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/68667
Mouse Swissprot No.
Q7TN37
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q7TN37
Rat Gene Link
https://www.uniprot.org/uniprot/171143
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q9ESQ5
免疫原
Synthesized peptide derived from human TRPM4 AA range: 1089-1139
特异性
This antibody detects endogenous levels of TRPM4 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a calcium-activated nonselective ion channel that mediates transport of monovalent cations across membranes, thereby depolarizing the membrane. The activity of the encoded protein increases with increasing intracellular calcium concentration, but this channel does not transport calcium. [provided by RefSeq, Mar 2016],
组织表达
Widely expressed with a high expression in intestine and prostate. In brain, it is both expressed in whole cerebral arteries and isolated vascular smooth muscle cells. Prominently expressed in Purkinje fibers. Expressed at higher levels in T-helper 2 (Th2) cells as compared to T-helper 1 (Th1) cells. Expressed in keratocytes (PubMed:30528822).
细胞定位
[Isoform 1]: Cell membrane ; Multi-pass membrane protein . Endoplasmic reticulum . Golgi apparatus .; [Isoform 2]: Cell membrane . Endoplasmic reticulum. Golgi apparatus.
功能
enzyme regulation:Gating is voltage-dependent and repressed by decavanadate. Calmodulin-binding confers the Ca(2+) sensitivity. ATP is able to restore Ca(2+) sensitivity after desensitization. Phosphatidylinositol 4,5-biphosphate (PIP2)-binding strongly enhances activity, by increasing the channel's Ca(2+) sensitivity and shifting its voltage dependence of activation towards negative potentials. Activity is also enhanced by 3,5-bis(trifluoromethyl)pyrazole derivative (BTP2).,function:Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload.,PTM:Phosphorylation by PKC leads to increase the sensitivity to Ca(2+).,sequence caution:Translated as Glu.,similarity:Belongs to the transient receptor family. LTrpC subfamily.,subunit:Homomultimer.,tissue specificity:Widely expressed with a high expression in intestine and prostaste. In brain, it is both expressed in whole cerebral arteries and isolated vascular smooth muscle cells.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
