产品名称
CRGC Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/1420
Human Swissprot No.
P07315
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P07315/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/12966
Mouse Swissprot No.
Q61597
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q61597
Rat Gene Link
https://www.uniprot.org/uniprot/24277
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P02529
免疫原
Synthesized peptide derived from human CRGC AA range: 45-95
特异性
This antibody detects endogenous levels of CRGC at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the beta/gamma-crystallin family of proteins. Crystallins constitute the major proteins of vertebrate eye lens and maintain the transparency and refractive index of the lens. This gene and several family members are present in a gene cluster on chromosome 2. Mutations in this gene have been shown to cause multiple types of cataract, including Coppock-like cataract and zonular pulverulent cataract, among others. [provided by RefSeq, Jan 2015],
功能
disease:Crystallins do not turn over as the lens ages, providing ample opportunity for post-translational modifications or oxidations. These modifications may change crystallin solubility properties and favor senile cataract.,disease:Defects in CRYGC are a cause of autosomal dominant cataract [MIM:604219]. Cataract is an opacification of the eye lens that frequently results in visual impairment or blindness during infancy and early childhood.,disease:Defects in CRYGC are a cause of Coppock-like cataract (CCL) [MIM:604307]. The Coppock cataract refers to a congenital pulverulent disk-like opacity involving the embryonal and fetal nucleus with many tiny white dots in the lamellar portion of the lens. It is usually bilateral and dominantly inherited.,disease:Defects in CRYGC are the cause of variable zonular pulverulent cataract [MIM:123680].,domain:Has a two-domain beta-structure, folded into four very similar Greek key motifs.,function:Crystallins are the dominant structural components of the vertebrate eye lens.,mass spectrometry: PubMed:12876325,similarity:Belongs to the beta/gamma-crystallin family.,similarity:Contains 4 beta/gamma crystallin 'Greek key' domains.,subunit:Monomer.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
