产品名称
TRAIP Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/10293
Human Swissprot No.
Q9BWF2
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9BWF2/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/22036
Mouse Swissprot No.
Q8VIG6
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8VIG6
免疫原
Synthesized peptide derived from human TRAIP AA range: 399-449
特异性
This antibody detects endogenous levels of TRAIP at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein that contains an N-terminal RING finger motif and a putative coiled-coil domain. A similar murine protein interacts with TNFR-associated factor 1 (TRAF1), TNFR-associated factor 2 (TRAF2), and cylindromatosis. The interaction with TRAF2 inhibits TRAF2-mediated nuclear factor kappa-B, subunit 1 activation that is required for cell activation and protection against apoptosis. [provided by RefSeq, Jul 2008],
细胞定位
Nucleus, nucleoplasm . Nucleus, nucleolus . Chromosome . Cytoplasm. Cytoplasm, perinuclear region . In the nucleus, found in close proximity to PCNA, suggesting localization at replication foci (PubMed:26595769). Localizes to DNA damage sites in response to replication stress (PubMed:26781088, PubMed:26595769, PubMed:26711499). .
功能
function:Inhibits activation of NF-kappa-B mediated by TNF.,similarity:Contains 1 RING-type zinc finger.,subunit:Binds TRAF1 and TRAF2 and is part of the receptor-TRAF signaling complex (By similarity). Interacts with CYLD.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
