产品名称
CHST7 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/56548
Human Swissprot No.
Q9NS84
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9NS84/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/60322
Mouse Swissprot No.
Q9EP78
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9EP78
Rat Gene Link
https://www.uniprot.org/uniprot/302302
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q6XQG8
免疫原
Synthesized peptide derived from human CHST7 AA range: 299-349
特异性
This antibody detects endogenous levels of CHST7 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is a member of the Gal/GalNAc/GlcNAc (galactose/N-acetylgalactosamine/N-acetylglucosamine) 6-O-sulfotransferase (GST) family. Members of this family encode enzymes that catalyze the specific addition of sulfate groups to distinct hydroxyl and amino groups of carbohydrates. The encoded protein catalyzes the sulfation of 6-hydroxyl group of GalNAc in chondroitin. [provided by RefSeq, Aug 2013],
组织表达
Widely expressed. Highly expressed in heart, spleen, liver and ovary. Expressed at lower level in brain, placenta, thyroid, spinal cord and peripheral blood leukocytes. Not expressed in adult skin.
细胞定位
Golgi apparatus membrane ; Single-pass type II membrane protein .
功能
catalytic activity:3'-phosphoadenylyl sulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate.,function:Catalyzes the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues. Preferentially acts on mannose-linked GlcNAc. Also able to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Also acts on core 2 mucin-type oligosaccharide and N-acetyllactosamine oligomer with a lower efficiency. Has weak or no activity toward keratan sulfate and oligosaccharides containing the Galbeta1-4GlcNAc. Catalyzes 6-O-sulfation of beta-benzyl GlcNAc but not alpha- or beta-benzyl GalNAc.,online information:GlycoGene database,similarity:Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.,tissue specificity:Widely expressed. Highly expressed in heart, spleen, liver and ovary. Expressed at lower level in brain, placenta, thyroid, spinal cord and peripheral blood leukocytes. Not expressed in adult skin.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
