产品名称
NSD3 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/54904
Human Swissprot No.
Q9BZ95
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9BZ95/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/234135
Mouse Swissprot No.
Q6P2L6
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q6P2L6
免疫原
Synthesized peptide derived from human NSD3 AA range: 1373-1423
特异性
This antibody detects endogenous levels of NSD3 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is related to the Wolf-Hirschhorn syndrome candidate-1 gene and encodes a protein with PWWP (proline-tryptophan-tryptophan-proline) domains. This protein methylates histone H3 at lysine residues 4 and 27, which represses gene transcription. Two alternatively spliced variants have been described. [provided by RefSeq, May 2015],
组织表达
Highly expressed in brain, heart and skeletal muscle. Expressed at lower level in liver and lung.
细胞定位
Nucleus . Chromosome .
功能
catalytic activity:S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N(6)-methyl-L-lysine.,disease:A chromosomal aberration involving WHSC1L1 is found in childhood acute myeloid leukemia. Translocation t(8;11)(p11.2;p15) with NUP98.,disease:Defects in WHSC1L1 may be involved in non small cell lung carcinomas (NSCLC). Amplified or overexpressed in NSCLC.,function:Histone methyltransferase. Preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the histone-lysine methyltransferase family. SET2 subfamily.,similarity:Contains 1 AWS domain.,similarity:Contains 1 post-SET domain.,similarity:Contains 1 SET domain.,similarity:Contains 2 PWWP domains.,similarity:Contains 4 PHD-type zinc fingers.,tissue specificity:Highly expressed in brain, heart and skeletal muscle. Expressed at lower level in liver and lung.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.