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NSD3 Rabbit Polyclonal Antibody

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产品基本信息

产品货号
BD-PN3957
产品名称
NSD3 Rabbit Polyclonal Antibody
类别
常规抗体
基因名称
WHSC1L1 NSD3 DC28
蛋白名称
NSD3
推荐应用
WB
反应种属
Human,Mouse
浓度
1 mg/ml
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene ID
54904
Human Gene Link
https://www.uniprot.org/uniprot/54904
Human Swissprot No.
Q9BZ95
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9BZ95/entry
Mouse Gene ID
234135
Mouse Gene Link
https://www.uniprot.org/uniprot/234135
Mouse Swissprot No.
Q6P2L6
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q6P2L6
免疫原
Synthesized peptide derived from human NSD3 AA range: 1373-1423
特异性
This antibody detects endogenous levels of NSD3 at Human/Mouse
稀释度
WB 1:500-2000
参考分子量
158kD
运输及保存条件
-20°C/1 year
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is related to the Wolf-Hirschhorn syndrome candidate-1 gene and encodes a protein with PWWP (proline-tryptophan-tryptophan-proline) domains. This protein methylates histone H3 at lysine residues 4 and 27, which represses gene transcription. Two alternatively spliced variants have been described. [provided by RefSeq, May 2015],
组织表达
Highly expressed in brain, heart and skeletal muscle. Expressed at lower level in liver and lung.
细胞定位
Nucleus . Chromosome .
功能
catalytic activity:S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N(6)-methyl-L-lysine.,disease:A chromosomal aberration involving WHSC1L1 is found in childhood acute myeloid leukemia. Translocation t(8;11)(p11.2;p15) with NUP98.,disease:Defects in WHSC1L1 may be involved in non small cell lung carcinomas (NSCLC). Amplified or overexpressed in NSCLC.,function:Histone methyltransferase. Preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the histone-lysine methyltransferase family. SET2 subfamily.,similarity:Contains 1 AWS domain.,similarity:Contains 1 post-SET domain.,similarity:Contains 1 SET domain.,similarity:Contains 2 PWWP domains.,similarity:Contains 4 PHD-type zinc fingers.,tissue specificity:Highly expressed in brain, heart and skeletal muscle. Expressed at lower level in liver and lung.,
期货
现货
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

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