产品名称
Beclin-1(5C2)Mouse Monoclonal Antibody
反应种属
Human,Rat,Mouse,Bovine
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8678
Human Swissprot No.
Q14457
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q14457/entry
Mouse Swissprot No.
O88597
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O88597
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q91XJ1
免疫原
Synthetic Peptide of Beclin-1 at AA range of 110-190
特异性
Beclin-1 protein detects endogenous levels of BECN1
稀释度
WB 1:1000-2000, IHC 1:100-200. IF 1:50-200
背景介绍
beclin 1(BECN1) Homo sapiens This gene encodes a protein that regulates autophagy, a catabolic process of degradation induced by starvation. The encoded protein is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking processes. This protein is thought to play a role in multiple cellular processes, including tumorigenesis, neurodegeneration and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015],
细胞定位
Cytoplasm . Golgi apparatus, trans-Golgi network membrane ; Peripheral membrane protein . Endosome membrane ; Peripheral membrane protein . Endoplasmic reticulum membrane ; Peripheral membrane protein . Mitochondrion membrane ; Peripheral membrane protein . Endosome . Cytoplasmic vesicle, autophagosome . Interaction with ATG14 promotes translocation to autophagosomes. Expressed in dendrites and cell bodies of cerebellar Purkinje cells (By similarity). .; [Beclin-1-C 35 kDa]: Mitochondrion . Nucleus . Cytoplasm .; [Beclin-1-C 37 kDa]: Mitochondrion .
信号通路
Regulation of autophagy;
功能
function:Plays a central role in autophagy (By similarity). May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus.,similarity:Belongs to the beclin family.,subcellular location:Expressed in dendrites and cell bodies of cerebellar Purkinje cells.,subunit:Interacts with GOPC and GRID2. Interacts with AMBRA1. Probably forms a complex with AMBRA1 and PIK3C3 (By similarity). Interacts with BCL2 and BCL2L1.,tissue specificity:Ubiquitous.,
纯化
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
