产品名称
TTC5 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/91875
Human Swissprot No.
Q8N0Z6
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8N0Z6/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/219022
Mouse Swissprot No.
Q99LG4
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q99LG4
Rat Gene Link
https://www.uniprot.org/uniprot/305837
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5BK48
免疫原
Synthesized peptide derived from human TTC5 AA range: 82-132
特异性
This antibody detects endogenous levels of TTC5 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
细胞定位
Nucleus . Cytoplasm . Cytoplasmic vesicle . Mitochondrion matrix . Phosphorylation at Ser-203 results in nuclear localization, while unphosphorylated protein localizes to the cytoplasm. Nuclear localization may be necessary for DNA damage-dependent stabilization of the protein. .
功能
function:Adapter protein involved in p53/TP53 response that acts by regulating and mediating the assembly of multi-protein complexes. Required to facilitate the interaction between JMY and p300/EP300 and increase p53/TP53-dependent transcription and apoptosis. Prevents p53/TP53 degradation by MDM2.,PTM:Phosphorylation at Ser-203 enhances protein stability, regulates nuclear accumulation and association with p300/EP300.,similarity:Contains 4 TPR repeats.,subcellular location:Phosphorylation at Ser-203 results in nuclear localization, while unphosphorylated protein localizes to the cytoplasm.,subunit:Interacts with JMY and p300/EP300.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
