产品名称
KLF10 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/7071
Human Swissprot No.
Q13118
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q13118/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/21847
Mouse Swissprot No.
O89091
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O89091
Rat Gene Link
https://www.uniprot.org/uniprot/81813
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/O08876
免疫原
Synthesized peptide derived from human KLF10 AA range: 228-278
特异性
This antibody detects endogenous levels of KLF10 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of a family of proteins that feature C2H2-type zinc finger domains. The encoded protein is a transcriptional repressor that acts as an effector of transforming growth factor beta signaling. Activity of this protein may inhibit the growth of cancers, particularly pancreatic cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013],
功能
function:Transcriptional repressor involved in the regulation of cell growth. Inhibits cell growth. Binds to the consensus sequence 5'-GGTGTG-3'.,induction:By TGF-beta.,PTM:Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.,similarity:Belongs to the Sp1 C2H2-type zinc-finger protein family.,similarity:Contains 3 C2H2-type zinc fingers.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
