产品名称
SC5AC Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/159963
Human Swissprot No.
Q1EHB4
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q1EHB4/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/241612
Mouse Swissprot No.
Q49B93
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q49B93
免疫原
Synthesized peptide derived from human SC5AC AA range: 84-134
特异性
This antibody detects endogenous levels of SC5AC at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
Normal blood lactate is maintained at about 1.5 mM, and little filtered lactate is excreted in urine. Reabsorption of lactate is mediated by the low-affinity Na(+)-coupled lactate transporter SLC5A12 in the initial part of the proximal tubule and by the high-affinity Na(+)-coupled lactate transporter SLC5A8 (MIM 608044) in the distal proximal tubule (Gopal et al., 2007 [PubMed 17692818]).[supplied by OMIM, Dec 2008],
细胞定位
Apical cell membrane ; Multi-pass membrane protein . Detected at the brush border membrane of the kidney. Colocalizes with viementin in Mueller cells (By similarity). .
功能
function:Acts as an electroneutral and low-affinity sodium (Na(+))-dependent sodium-coupled solute transporter. Catalyzes the transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, nicotinate, propionate, butyrate and beta-D-hydroxybutyrate. May be responsible for the first step of reabsorption of monocarboxylates from the lumen of the proximal tubule of the kidney and the small intestine. May play also a role in monocarboxylates transport in the retina (By similarity). Mediates electroneutral uptake of lactate, with a stoichiometry of 2 Na(+) for each lactate.,miscellaneous:Cotransport of monocarboxylates and nicotinate strongly inhibited by ibuprofen, fenoprofen and ketoprofen.,similarity:Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.,subcellular location:Detected at the brush border membrane of the kidney. Colocalizes with viementin in Mueller cells.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
