产品名称
U119A Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/9094
Human Swissprot No.
Q13432
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q13432/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/22248
Mouse Swissprot No.
Q9Z2R6
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9Z2R6
Rat Gene Link
https://www.uniprot.org/uniprot/29402
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q62885
免疫原
Synthesized peptide derived from human U119A AA range: 153-203
特异性
This antibody detects endogenous levels of U119A at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is specifically expressed in the photoreceptors in the retina. The encoded product shares strong homology with the C. elegans unc119 protein and it can functionally complement the C. elegans unc119 mutation. It has been localized to the photoreceptor synapses in the outer plexiform layer of the retina, and suggested to play a role in the mechanism of photoreceptor neurotransmitter release through the synaptic vesicle cycle. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008],
组织表达
Abundantly expressed in retina, in photoreceptor synapses and inner segments. Expressed in a much lesser extent in several other tissues.
细胞定位
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle pole . Cytoplasm, cytoskeleton, spindle . Localizes to the centrosome in interphase cells and begins to translocate from the spindle pole to the spindle midzone after the onset of mitosis; it then localizes to the intercellular bridge in telophase cells and to the midbody in cytokinetic cells. .
功能
function:May play a role in the mechanism of photoreceptor neurotransmitter release through the synaptic vesicle cycle.,similarity:Belongs to the PDE6D/unc-119 family.,tissue specificity:Retinal-specific. Localized in photoreceptor synapses in the outer plexiform layer of the retina.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.