产品名称
SMOX Rabbit Polyclonal Antibody
基因名称
SMOX C20orf16 SMO UNQ3039/PRO9854
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/54498
Human Swissprot No.
Q9NWM0
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9NWM0/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/228608
Mouse Swissprot No.
Q99K82
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q99K82
免疫原
Synthesized peptide derived from human SMOX AA range: 212-262
特异性
This antibody detects endogenous levels of SMOX at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
Polyamines are ubiquitous polycationic alkylamines which include spermine, spermidine, putrescine, and agmatine. These molecules participate in a broad range of cellular functions which include cell cycle modulation, scavenging reactive oxygen species, and the control of gene expression. These molecules also play important roles in neurotransmission through their regulation of cell-surface receptor activity, involvement in intracellular signalling pathways, and their putative roles as neurotransmitters. This gene encodes an FAD-containing enzyme that catalyzes the oxidation of spermine to spermadine and secondarily produces hydrogen peroxide. Multiple transcript variants encoding different isoenzymes have been identified for this gene, some of which have failed to demonstrate significant oxidase activity on natural polyamine substrates. The characterized isoenzymes have distinctive biochemical characteristics and substrate specificities, suggesting the existence of additional levels of complexity in polyamine catabolism. [provided by RefSeq, Jul 2012],
组织表达
Widely expressed. Expressed in human tumor cell lines. Isoform 4 is only found in an embryonal kidney cell line.
细胞定位
[Isoform 1]: Cytoplasm. Nucleus.; [Isoform 4]: Cytoplasm. Nucleus.; [Isoform 6]: Cytoplasm. Nucleus.
功能
alternative products:At least 5 different isozymes are produced by alternative splicing of 8 exons. The resultant proteins have different biochemical characteristics and substrate specificity,catalytic activity:Spermidine + O(2) + H(2)O = putrescine + 3-aminopropanal + H(2)O(2).,catalytic activity:Spermine + O(2) + H(2)O = spermidine + 3-aminopropanal + H(2)O(2).,cofactor:Binds 1 FAD per subunit.,enzyme regulation:Inhibited at more than 90% by SL-11144, SL-11150 and SL-11158, at concentrations less than 1uM.,function:Flavoenzyme which catalyzes the oxidation of spermine to spermidine. Can also use N(1)-acetylspermine and spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental conditions. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. May contribute to beta-alanine production via aldehyde dehydrogenase conversion of 3-amino-propanal.,induction:By antitumor polyamine analogs.,pathway:Amine and polyamine degradation; spermine degradation.,similarity:Belongs to the flavin monoamine oxidase family.,tissue specificity:Widely expressed.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
