产品名称
RN5A Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/6041
Human Swissprot No.
Q05823
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q05823/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/24014
Mouse Swissprot No.
Q05921
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q05921
免疫原
Synthesized peptide derived from human RN5A AA range: 248-298
特异性
This antibody detects endogenous levels of RN5A at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele. [provided by RefSeq, Jul 2008],
组织表达
Highly expressed in spleen and thymus followed by prostate, testis, uterus, small intestine, colon and peripheral blood leukocytes.
细胞定位
Cytoplasm . Mitochondrion .
功能
catalytic activity:Cleaves 3' of UpNp dimers, with preference for UU and UA sequences, to sets of discrete products ranging from between 4 and 22 nucleotides in length.,cofactor:Manganese or magnesium. Required for optimal RNA cleavage rates.,disease:Defects in RNASEL may be the cause of susceptibility to hereditary prostate cancer 1 (HPC1) [MIM:176807, 601518].,domain:The nine ankyrin repeats also called 2-5A sensor constitute the 2-5A binding domain.,domain:The protein kinase domain is predicted to be catalytically inactive. It allows the homodimerization.,enzyme regulation:After binding to 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) the homodimerization and subsequent activation occurs. Inhibited by RNase L inhibitor.,function:Endoribonuclease, mediator of interferon action, which play a role in mediating resistance to virus infection and apoptosis. Might play a central role in the regulation of mRNA turnover.,induction:By interferons.,similarity:Belongs to the protein kinase superfamily.,similarity:Contains 1 KEN domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 9 ANK repeats.,subunit:Monomer (inactive form) or homodimer.,tissue specificity:Highly expressed in spleen and thymus followed by prostate, testis, uterus, small intestine, colon and peripheral blood leukocytes.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
