产品名称
POLD4 Rabbit Polyclonal Antibody
别名
DNA polymerase delta subunit 4 (DNA polymerase delta subunit p12)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Swissprot No.
Q9HCU8
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9HCU8/entry
免疫原
Synthesized peptide derived from human POLD4 AA range: 43-93
特异性
This antibody detects endogenous levels of human POLD4
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes the smallest subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein enhances the activity of DNA polymerase delta and plays a role in fork repair and stabilization through interactions with the DNA helicase Bloom syndrome protein. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012],
组织表达
Brain,Cervix,Ovarian carcinoma,Pooled,
细胞定位
Nucleus . Partially recruited to DNA damage sites within 2 hours following UV irradiation, before degradation. .
功能
function:Required for optimal DNA polymerase delta activity. May contribute to PCNA-dependent activity of DNA polymerase delta.,similarity:Belongs to the DNA polymerase delta subunit 4 family.,subunit:Heterotetramer composed of subunits of 125 kDa, 50 kDa, 66 kDa and 12 kDa. Interacts with WRNIP1. Interacts with POLD4, POLD2, POLD1 and PCNA.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
