产品名称
Cyclin T2 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Swissprot No.
O60583
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O60583/entry
免疫原
Synthesized peptide derived from human Cyclin T2 AA range: 510-590
特异性
This antibody detects endogenous levels of human Cyclin T2
稀释度
IHC-p 1:50-200, WB 1:500-2000. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin and its kinase partner CDK9 were found to be subunits of the transcription elongation factor p-TEFb. The p-TEFb complex containing this cyclin was reported to interact with, and act as a negative regulator of human immunodeficiency virus type 1 (HIV-1) Tat protein. A pseudogene of this gene is found on chromosome 1. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010],
组织表达
Ubiquitously expressed.
细胞定位
Cytoplasm, perinuclear region . Nucleus . Nucleus in differentiating cells. .
功能
function:Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II).,similarity:Belongs to the cyclin family. Cyclin C subfamily.,subunit:Associates with CDK9 to form P-TEFb. Isoform A and isoform B interact with HIV-2 and SIV Tat. Does not bind efficiently to the transactivation domain of the HIV-1 Tat.,tissue specificity:Ubiquitously expressed.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
