产品名称
GRASP Rabbit Polyclonal Antibody
别名
General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Swissprot No.
Q7Z6J2
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q7Z6J2/entry
免疫原
Synthesized peptide derived from human GRASP
特异性
This antibody detects endogenous levels of human GRASP
稀释度
IHC-p 1:50-200, WB 1:500-2000. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein that functions as a molecular scaffold, linking receptors, including group 1 metabotropic glutamate receptors, to neuronal proteins. The encoded protein contains conserved domains, including a leucine zipper sequence, PDZ domain and a C-terminal PDZ-binding motif. Alternately spliced transcript variants have been observed for this gene.[provided by RefSeq, Dec 2012],
细胞定位
Cytoplasm, perinuclear region . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell junction, synapse, postsynaptic cell membrane .
功能
function:Plays a role in intracellular trafficking and contributes to the macromolecular organization of group 1 metabotropic glutamate receptors (mGluRs) at synapses.,similarity:Contains 1 PDZ (DHR) domain.,subcellular location:Localized at postsynaptic membranes.,subunit:Heteromer. Composed of GRASP, PSCD2 and at least one GRM1. Also interacts with PSCD3, GRM2, GRM3 and GRM5.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
