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Adrenocorticotropin(ACTH) Rabbit Polyclonal Antibody

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产品基本信息

产品货号
BD-PT6193
产品名称
Adrenocorticotropin(ACTH) Rabbit Polyclonal Antibody
别名
Pro-opiomelanocortin (POMC;Corticotropin-lipotropin) [Cleaved into: NPP; Melanotropin gamma (Gamma-MSH); Potential peptide; Corticotropin (Adrenocorticotropic hormone;ACTH); Melanotropin alpha (Alpha-MSH); Corticotropin-like intermediary peptide (CLIP); Lipotropin beta (Beta-LPH); Lipotropin gamma (Gamma-LPH); Melanotropin beta (Beta-MSH); Beta-endorphin; Met-enkephalin]
类别
常规抗体
基因名称
POMC
蛋白名称
Adrenocorticotropin(ACTH)
推荐应用
WB
反应种属
Human,Mouse,Rat
浓度
1 mg/ml
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene ID
5443
Human Swissprot No.
P01189
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P01189/entry
免疫原
Synthesized peptide derived from human Adrenocorticotropin(ACTH)
特异性
This antibody detects endogenous levels of human Adrenocorticotropin(ACTH)
稀释度
IHC-p 1:50-200, WB 1:500-2000. IF 1:50-200
预测分子量
29kD
运输及保存条件
-20°C/1 year
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a preproprotein that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the preproprotein and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. The
组织表达
ACTH and MSH are produced by the pituitary gland.
细胞定位
Secreted . Melanocyte-stimulating hormone alpha and beta-endorphin are stored in separate granules in hypothalamic POMC neurons, suggesting that secretion may be under the control of different regulatory mechanisms. .
功能
disease:Defects in POMC are the cause of pro-opiomelanocortinin deficiency [MIM:609734]. Affected individuals present early-onset obesity, adrenal insufficiency and red hair.,disease:Defects in POMC may be associated with susceptibility to obesity [MIM:601665].,function:ACTH stimulates the adrenal glands to release cortisol.,function:Beta-endorphin and Met-enkephalin are endogenous opiates.,function:MSH (melanocyte-stimulating hormone) increases the pigmentation of skin by increasing melanin production in melanocytes.,online information:Melanocyte-stimulating hormone entry,PTM:O-glycosylated; reducing sugar is probably N-acetylgalactosamine.,PTM:Specific enzymatic cleavages at paired basic residues yield the different active peptides.,similarity:Belongs to the POMC family.,tissue specificity:ACTH and MSH are produced by the pituitary gland.,
期货
现货
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

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