产品名称
TRY2 Rabbit Polyclonal Antibody
别名
Trypsin-2 (EC 3.4.21.4;Anionic trypsinogen;Serine protease 2;Trypsin II)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Swissprot No.
P07478
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P07478/entry
免疫原
Synthesized peptide derived from human TRY2
特异性
This antibody detects endogenous levels of human TRY2
稀释度
IHC-p 1:50-200, WB 1:500-2000. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. This protein has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, this enzyme is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2015],
组织表达
Expressed in Paneth cells, at the base of small intestinal crypts.
细胞定位
Secreted, extracellular space.
功能
catalytic activity:Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.,cofactor:Binds 1 calcium ion per subunit.,PTM:Sulfated on tyrosine.,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 peptidase S1 domain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
