产品名称
IDHP Rabbit Polyclonal Antibody
别名
Isocitrate dehydrogenase [NADP], mitochondrial (IDH;EC 1.1.1.42;ICD-M;IDP;NADP(+)-specific ICDH;Oxalosuccinate decarboxylase)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Swissprot No.
P48735
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P48735/entry
免疫原
Synthesized peptide derived from human IDHP
特异性
This antibody detects endogenous levels of human IDHP
稀释度
IHC-p 1:50-200, WB 1:500-2000. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. Alternative splicing results in multiple transcript variants. [provided by Ref
组织表达
Colon,Heart,Kidney,Skin,
功能
catalytic activity:Isocitrate + NADP(+) = 2-oxoglutarate + CO(2) + NADPH.,catalytic activity:Oxalosuccinate + NADP(+) = 2-oxoglutarate + CO(2) + NADPH.,cofactor:Binds 1 magnesium or manganese ion per subunit.,function:Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex.,similarity:Belongs to the isocitrate and isopropylmalate dehydrogenases family.,subunit:Homodimer.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
