BD-PT6162

PAR1 (Cleaved-Ser42) Rabbit Polyclonal Antibody

Proteinase-activated receptor 1 (PAR-1) (Coagulation factor II receptor) (Thrombin receptor)

常规抗体

F2R CF2R PAR1 TR

Proteinase-activated receptor 1 (PAR-1) (Coagulation factor II receptor) (Thrombin receptor)

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

2149

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2149

P25116

http://www.uniprot.org/uniprotkb/P25116/entry

14062

P30558

http://www.uniprot.org/uniprot/P30558

P26824

http://www.uniprot.org/uniprot/O54941P26824

Synthesized peptide derived from human PAR1 (Cleaved-Ser42) Polyclonal

This antibody detects endogenous levels of PAR1 (Cleaved-Ser42).

WB 1:500-2000, ELISA 1:10000-20000

46kD

-20°C/1 year

Polyclonal, Rabbit,IgG

Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015],

Platelets and vascular endothelial cells.

Cell membrane; Multi-pass membrane protein.

Calcium;Neuroactive ligand-receptor interaction;Endocytosis;Complement and coagulation cascades;Regulates Actin and Cytoskeleton;

function:High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.,PTM:A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.,PTM:Phosphorylated; probably mediating desensitization prior to the uncoupling and internalization of the receptor.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Platelets and vascular endothelial cells.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.