产品名称
CHCHD4 Rabbit Polyclonal Antibody
别名
Mitochondrial intermembrane space import and assembly protein 40 (Coiled-coil-helix-coiled-coil-helix domain-containing protein 4)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.03% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/131474
Human Swissprot No.
Q8N4Q1
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8N4Q1/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/72170
Mouse Swissprot No.
Q8VEA4
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8VEA4
Rat Gene Link
https://www.uniprot.org/uniprot/100361898
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5BJN5
免疫原
Synthesized peptide derived from human CHCHD4 AA range: 35-85
特异性
This antibody detects endogenous levels of CHCHD4 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
CHCHD4, a component of human mitochondria, belongs to a protein family whose members share 6 highly conserved cysteine residues constituting a -CXC-CX(9)C-CX(9)C- motif in the C terminus (Hofmann et al., 2005 [PubMed 16185709]).[supplied by OMIM, Mar 2008],
组织表达
Expressed in all tissues tested, suggesting an ubiquitous expression.
细胞定位
Mitochondrion intermembrane space .
功能
domain:The CHCH domain contains a conserved twin Cys-X(9)-Cys motif which is required for import and stability of MIA40 in mitochondria.,function:Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Probably acts by forming a redox cycle with GFER/ERV1 that involves a disulfide relay system. Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS.,PTM:Forms intrachain disulfide bridges, but exists in different redox states.,similarity:Contains 1 CHCH domain.,subunit:Forms homooligomer.,tissue specificity:Expressed in all tissues tested, suggesting an ubiquitous expression.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
